Commentary 2.p65
نویسنده
چکیده
The bioavailability of drugs is determined by gastrointestinal physiological factors and the physicochemical property of drugs. The presence of food changes the physiological functions of gastrointestinal mucosa (e.g., gastric pH, gastric emptying, hepatic blood flow) which may lead to increase or decrease in the bioavailability of drugs. Intestinal absorption of penicillin, captopril, ciprofloxacin, quinidine and zidovudine was reported to be reduced when given with food. On the other hand, bioavailability of clarithromycin, griseofulvin and leukotriene antagonists was increased by the presence of food. It is difficult to predict the interaction of drug with food based on its chemical structure.
منابع مشابه
Commentary 2.p65
von Willebrand factor (VWF) is a large plasma glycoprotein that exists as a series of multimers of molecular weight 800-20000 kD. VWF has two main functions: as a carrier protein for coagulation factor VIII and as an adhesive protein involved in vessel wall-platelet interaction. Its function as an adhesive protein is most important in situations of high shear stress. Inherited defects in VWF ma...
متن کاملاثر مهاری کورکومین بر فسفریلاسیون NFκB-p65 القاشده توسط هیدروژن پراکسید در سلول‌های اندوتلیال آئورت گاوی
زمینه و هدف: NFκB یک فاکتور هسته‌ای دایمر و دارای چندین زیرواحد است. p65 یکی از زیرواحدهای NFκB است که فسفریلاسیون آن در اثر استرس اکسیداتیو به فعال شدن NFκB منجر می‌گردد. عدم تعادل میان استرس اکسیداتیو و ظرفیت آنتی‌اکسیدانی در پاتوژنز بسیاری بیماری‌ها مشارکت می‌کند. استفاده از ترکیبات آنتی‌اکسیدانی می‌تواند به‌عنوان استراتژی پیشگیری بیماری‌های التهابی موردتوجه قرار گیرد. از میان ترکیبات آنتی‌ا...
متن کاملThe effects of adenosine injection after of brain ischemia reperfusion injury on gene expression of NF-kB/p65 and activity level of ROS in male Wistar rats
Background: Unit of p65 is one of the subunits of NF-κB and its phosphorylation by stress oxidative causes activation of NF-κB. The aim of present study was to investigate the effects of adenosine injection after brain ischemia reperfusion injury on gene expression of NF-κB /p65 and Reactive Oxygen Species (ROS) in hippocampus tissue of male wistar rats. Methods: 40 male wistar rats were rando...
متن کاملP65: Treatment of Spinal Cord Injury Using Transplantation of Adipose Mesenchymal Stem Cells Transfected with Poly-L-Lysine/ DNA (GDNF) - Super Paramagnetic Iron Oxide Nanoparticles
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملNuclear NF-κB p65 in Peripheral Blood Mononuclear Cells Correlates with Urinary MCP-1, RANTES and the Severity of Type 2 Diabetic Nephropathy
AIMS To investigate if nuclear NF-κB p65 expression in ex vivo isolated peripheral blood mononuclear cells correlates with urinary MCP-1 or RANTES and the severity of type 2 diabetic nephropathy. METHODS According to their urinary albumin-to-creatinine ratio (uACR), 107 patients with type 2 diabetes (eGFR >60 ml/min) were divided into normal albuminuria group (DN0 group, 38 cases), microalbum...
متن کامل